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Last updated: July 24, 2026 at 8:35 PM ET

cerevisiae PNS1 (pH nine-sensitive protein 1), and Arabidopsis thaliana CherI (Choline Transporter-like 1) (23, 24)

While these results are broadly in line with the previously reported role of activated KRAS in supporting de novo serine synthesis 17 , it is clear that other genetic alterations such as amplification of PHGDH in MDA-MB-468 cells 14 also contribute to the dependence of cancer cells on a supply of exogenous serine