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In an acidic environment, ACP exerts an immune function by recognizing and catalyzing the hydrolysis of phosphate bonds of foreign substances to degrade or destroy pathogens

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Another small study suggests that HFR could alleviate the pruritus associated with CKD,78 a symptom that has a negative impact on quality of life.79 There is a lack studies that specifically compared the mortality associated with HFR with respect to other HD modalities,80 so it is still unknown whether the previously mentioned benefits of the technique on the inflammatory and nutritional status of patients are translated into increased survival

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