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Signal recognition particles Universally conserved ribonucleoproteins that recognizes and targets specific proteins to the endoplasmic reticulum ER-associated degradation: (ERAD) The cellular pathway which targets misfolded proteins of the endoplasmic reticulum for ubiquitination and subsequent degradation by the proteasome

Subsequently, glutamate dehydrogenase 1 (GLUD1) or multiple mitochondrial transaminases, such as alanine aminotransferase 2 (GPT2) and aspartate aminotransferase 2 (GOT2), convert mitochondrial glutamate to -KG (Fig

Because it is a powerful detoxifier, it could also theoretically speed up the metabolism of other drugs, making them less effective

Honjo et al., 2011

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