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Gonadotropin-releasing hormone (GnRH), produced by hypothalamic neuroendocrine neurons, is delivered through the hypophyseal portal circulation to the anterior pituitary, where it binds to GnRH receptors on gonadotrophs and elicits the pulsatile secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) [24, 60]

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