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Despite the existence of several therapeutic modalities, namely psychotherapy and antidepressants, there are several problems associated with the therapy of this disease, such as the development of resistance and relapses after the end of therapy

In vitro and animal studies have found that lipoic acid exhibits immunomodulatory properties through mechanisms that stimulate the production of cyclic AMP (cAMP) (90, 91) a central regulator of innate immune functions and inhibits the migration of immune cells into the brain and spinal cord (92), possibly by decreasing endothelial expression of cell adhesion molecules, inhibiting expression of enzymes like matrix metalloproteinases (MMP), and/or reducing the permeability of the blood-brain barrier (87, 89, 93, 94)

IV Hydration & Recovery Proper hydration is critical for long COVID recovery, yet many patients stay chronically dehydrated because of dysautonomia and other complications

EBioMedicine 39 , 239254 (2019)

Note by PAS: The Nice Guideline referred to Pernicious Anaemia as autoimmune gastritis