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Phase II Clinical Trials These promising preclinical findings led to Phase I and Phase II clinical trials in humans

Following the transfer of aminopropyl groups, dcSAM transforms into 5-deoxy-5-methylthioadenosine, which then can undergo a series of steps in the Met salvage pathway to regenerate adenine and Met (Lauinger and Kaiser, 2021)

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29 Dietary sources of cysteine present as cystine (two cysteines linked by a disulfide bond) are more stable than free cysteine and properly digested

The glutathione addition onto electrophilic molecules is well-recognized and is mediated by specific classes of GSTs having usually a serine or a tyrosine as a catalytic residue