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Soltys DT, Rocha CRR, Lerner LK, de Souza TA, Munford V Cabral F et al

The overall effect of this dense irregular ECM deposition is to block drug diffusion and immune cell migration, reduce glucose and oxygen supply, increase drug efflux via hypoxia inducible factor 1 (HIF-1), increase survival (integrins), and reduce cell cycle arrest via FAK signaling [20]