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[Abstract]2025 Oct 1:e70110

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Tricyclic antidepressants TCAs are thought to relieve pain by inhibiting the reuptake of noradrenaline and serotonin in presynaptic neurons and by antagonizing N-methyl-D-aspartate receptors, which mediate hyperalgesia and allodynia [52-54]

Existing drugs for increasing HDL-C are primarily fibric acid derivatives (fibrates) and niacin-containing compounds, but recent studies have failed to show a clear benefit from raising HDL with these drugs