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Notably, RSL3 induced widespread depletion of the astrocyte-like signature in transformed glioma cells across patient samples, including several genes with important metabolic functions, such as FABP7 (fatty acid binding protein 7), involved in fatty acid and mitochondrial metabolism, DBI (Diazepam Binding Inhibitor, Acyl-CoA Binding Protein) involved in lipid metabolism, and GPM6B (glycoprotein M6B), membrane proteolipid with important roles in membrane trafficking (Fig

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In this assay, animals are orally gavaged with a solution containing FITC-Dextran (4-kDa), blood is collected and fluorescence measured using a typical laboratory plate reader with fluorescence detection [45]

The results showed that overlap between MBP immunoreactivity and neuronal fibers was significantly higher in crude HEM-treated cultures than in the control culture (Fig