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doi: 10.3390/ijms20092358 13 SamuelVTShulmanGI

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The inhibition of ISCA2 (a component of the late mitochondrial iron-sulfur cluster assembly complex) reduces the HIF-2 protein level and triggers an iron starvation response, leading to iron/metal overload and contributing to ferroptosis, which is more significant in VHL-defective cells (82)

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