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The study also investigated predictors of new-onset HFpEF in MASH patients without prior CVD, utilizing multivariate analysis to adjust for various factors including age, gender, race, comorbidities, and hospital characteristics

Component-resolved HPLC, dual-target LC-MS, and LAL endotoxin assays run in parallel, with results scored against pre-locked criteria

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These canonical functions positioned DHODH primarily as a metabolic enzyme critical for nucleotide biosynthesis and cellular proliferation, before its more recent identification as a mitochondria-specific ferroptosis suppressor in select cancer contexts