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Synthesis 54 , 255270 (2021)

"Randomized clinical trial to comparing the efficacy of daily, weekly and monthly administration of vitamin D3"

Mutations and DNA damage may also be caused by oxidative changes to DNA sugar-phosphate backbones, which can be induced by O 2 - generating enzymes like NADPH oxidase and mitochondria

Mechanistically, BL-mediated protection involves downregulation of IFN- production, attenuation of cytotoxic microglial activation and CD4 + T cell responses, expansion of Treg populations, and suppression of Th17 cell differentiation