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Sci Rep 10(1):7770

The idea is that if the drugged cells proliferate as usual, there is no advantage to or selection for mutants resistant to the evolution-slowing drug

Ingredients & Nutritional Profile

Voglino et al

Altered protein binding can affect drug responses because only the "free", unbound drug is active and for a highly protein-bound drug small changes in the extent of protein binding can substantially influence the free drug concentration [free drug]