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Normal human epidermal keratinocytes were cultivated under controlled laboratory conditions

Physiology 35, 302327

These classes include benzodiazepines, certain antidepressants, skeletal muscle relaxants, and NSAIDs

By disrupting the interconnected cascade of seizures, neuroinflammation, structural damage, and neurobehavioral deficits, SAR demonstrates translational potential to address critical gaps in the current medical countermeasures for chronic neurotoxicity

Abrupt withdrawal has been linked to severe complications, including Posterior Reversible Encephalopathy Syndrome (PRES), hypertensive encephalopathy, stroke, and death (Thorpe et al., 2025)