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doi: 10.1021/acssynbio.5c00236 40 ManjulaSBhavanPSKarthikMAnithaDKalpanaRManjulaT

Chronically elevated insulin, visceral fat, systemic inflammation, and oxidative stress are deeply intertwined with the hallmarks of aging (like cellular senescence and mitochondrial dysfunction)

As we further our understanding of parthanatos, new possibilities for therapeutic interventions directed at modulating this cell death pathway are discovered, especially in the context of oxidative stress-associated diseases

However, while alcohol may provide temporary relief, it often results in a vicious cycle where increased consumption leads to heightened depressive symptoms

[DOI] [PMC free article] [PubMed] [Google Scholar] 206.Han L., Liu J., Zhu L., Tan F., Qin Y., Huang H., Yu Y