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HIF-1 is a transcription factor that is stabilized under low oxygen (hypoxic) conditions and whose activity leads to the transcription of several metabolism genes such as hexokinase and glucose transporter-1 (Semenza, 2011)

Ros-Daz, J

Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species

Neurobiol Sleep Circadian Rhythms 5, 5867

However, IKK deficient mice die on 14 th day of gestation because of massive apoptosis of hepatocytes, therefore, these clinical trials have to be terminated [38, 121]