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(2017) 12:e0186802

Rational design of mitochondria-targeted pyruvate dehydrogenase kinase 1 inhibitors with improved selectivity and antiproliferative activity

While the medical use of opium in antiquity (first by Greco-Roman medicine and centuries later by Arab, Indian, and Chinese medicines) is well documented, reliable evidence of widespread recreational use is much more recent and appears to be related to technological innovations

There are studies investigating the effects of ozone application on platelet aggregation, but to our knowledge there is not any study investigating changes in RBC aggregation with ozone treatment in the literature except ours