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The pathogenic role of copper is context-dependent and exhibits a U-shaped risk curve

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In cells treated with ebselen, disulphide intact E,Zn-SOD1 is detected at levels comparable to those of wild-type SOD1, whereas in untreated cells the SOD1 mutants are either largely accumulated as unfolded species (G93A, see Fig

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Kreisl WC, Jenko KJ, Hines CS, Hyoung Lyoo C, Corona W, Morse CL, et al