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There are three aminotransferase pathways through which glutamate can be transformed to -KG

Roles of Chelation in Natural Toxicokinetics Metal binding proteins, including metallothioneins, are potent chelators for heavy metals and are central to the natural response of the body to these toxic elements [27, 28]

Molecular events initiating exit of a copper-transporting ATPase ATP7B from the trans-Golgi network

In the context of neurodegenerative diseases, the brains high oxygen consumption, abundant lipid content, and relatively low antioxidant capacity make it particularly vulnerable to oxidative stress [25,26,27]

Researchers have also studied this mechanism in relation to muscle-tissue models and general markers of cellular aging