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A dual-pathway pyroptosis inducer based on AuCu2-xSe@ZIF-8 enhances tumor immunotherapy by disrupting the zinc ion homeostasis

eLife 9, e60552

This ROS causes the oxidation of unsaturated fatty acids, proteins and DNA

In general, excess ROS causes the production of a few enzymes, such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, xanthine oxidase (XO), lipoxygenase (LO), cytochrome P450 (CYP450), myeloperoxidase (MPO), iron (Fe), and copper (Cu) proteins