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10.1155/2017/9124160 81 FredrikssonA.ArcherT

Week 2-3: Noticeable reduction in acute symptoms for most researchers

Supplementary material The Supplementary material for this article can be found online at: AMSTAR A MeaSurement Tool to Assess systematic Review BMI Body Mass Index CI Confidence Interval CRP C-reactive Protein DHA Docosahexaenoic Acid EPA Eicosapentaenoic Acid FBG Fasting Blood Glucose FG Fasting Glucose FI Fasting Insulin FSH Follicle-Stimulating Hormone GSH Glutathione HDL-C High-Density Lipoprotein Cholesterol HOMA-IR Homeostatic Model Assessment of Insulin Resistance hs-CRP high-sensitivity C-reactive Protein LDL-C Low-Density Lipoprotein Cholesterol LH Luteinizing Hormone MDA Malondialdehyde MD Mean Difference NO Nitric Oxide OR Odds Ratio PCOS Polycystic Ovary Syndrome PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses QUICKI Quantitative Insulin Sensitivity Check Index RCT Randomized Controlled Trial RR Risk Ratio SHBG Sex Hormone-Binding Globulin SMD Standardized Mean Difference TAC Total Antioxidant Capacity TC Total Cholesterol TG Triglycerides vLDL-C very Low-Density Lipoprotein Cholesterol WHR Waist-to-Hip Ratio Glossary References 1

In addition to the loss of motor function and subsequent muscle paralysis, incomplete repair leads to complications such as permanent neuropathic pain and the need for intensive care, diminishing the patients quality of life 3,6,7

The target PARK7/DJ-1 were identified as a drug target for the PD treatment based on significant measures with its threshold values mentioned in Table 1 and Supplementary Fig