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Indeed, the review of eight trials in children undergoing tonsillectomy (177), of which only two trials scored pain using the same scale, showed no pain reduction with magnesium compared to control

Future efforts should prioritize the development of robust experimental models, both in vitro and in vivo, taking advantage of immunocompetent models and single-cell and spatial multiomics technologies, alongside innovative tissue and liquid biopsies to monitor MRD, to accelerate the dynamic tracking and therapeutic exploitation of the DTP phenotype, with the ultimate goal of inducing long-lasting clinical responses in patients with cancer

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Astrocytic CB1 activation elicits astrocytic glutamate release that specifically induces activity from either D1 or D2 MSNs, but not both (Martn et al., 2015)

This subsequently causes Ca 2+ translocation, ROS production, and activation of cellular pathways