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All of these steps have an important significance, as indicated above, but the key aspect is perhaps the step via vitamin B12-dependent methionine synthase which links the entire methionine cycle directly to the folate cycle

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Worms were initially transferred from Novosphingobium L76 to NGM plates supplemented with 50 g/ml of kanamycin for one generation, then back to E

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Because crystalline formulations are better absorbed than naturally occurring vitamin B 12 , patients older than 50 years and strict vegetarians should consume foods fortified with vitamin B 12 and vitamin B 12 supplements, rather than attempting to get vitamin B 12 strictly from dietary sources