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Additionally, the NAD + -dependent deacetylase SIRT2 can also govern the metabolic fitness of immune cells by blocking the activities of key enzymes in multiple metabolic pathways, thus impairing effector functions of tumor-reactive T cells in the tumor microenvironment

Liu D, Chen X, He W, Lu M, Li Q, Zhang S

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[DOI] [PubMed] [Google Scholar] 18.Yue J., Peng R.X., Yang J., Kong R., Liu J