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10.1371/journal.pbio.3000473 PLoS Biol

Brain tissue is particularly vulnerable to OS and highly susceptible to oxygen radical damage because of its high oxygen consumption and lack of antioxidant enzymes

Critically, blood levels of ET peak in adolescence at approximately 3.7 mg/100 mL and then decline progressively with age

observed that DKD patients exhibit significant downregulation of glycine metabolic pathways, reduced glutathione levels, a decreased glutathione to oxidized glutathione ratio, and elevated malondialdehyde, contributing to cellular oxidative stress