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The role of trace metals in hematopoiesis

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PTP1B-deficient mice are protected against APAP-induced oxidative stress through the enhancement of Nrf2 nuclear accumulation Increased survival was observed in PTP1B / mice injected with an APAP overdose (300 mg/kg) as compared with the wild-type control (Figure 6a)

Gene x environment (GxE) interactions We quantified the resulting GxE interaction effects by calculating the Z -score of the LFC (relative to pDNA) using cutting control guides as the null distribution, which corrects for differences in growth rates between different conditions (Supplementary Data 2)

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