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doi: 10.1016/j.ejphar.2024.176399 40 HanJJLiXYeZQLuXYYangTTianJet al

The bloodbrain barrier (BBB) endothelial cells also play a critical role: they regulate the bidirectional transport of pathological proteins like -synuclein, and their dysfunction impairs protein clearance while promoting aggregation, thereby accelerating PD pathology