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Sperm DNA fragmentation is correlated with poor embryo development, lower implantation rate, and higher miscarriage rate in reproductive cycles of non-male factor infertility

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Most experimental data on DTP cells derive from in vitro cell line studies or short-term animal xenograft models that poorly represent tumor complexity and heterogeneity in patients ( Addressing these diverse challenges through a multidisciplinary approachintegrating precise biomarker development, advanced modeling, carefully designed clinical studies, and cautious therapeutic timingis paramount to fully exploiting DTP reversibility as a strategy for overcoming therapy resistance