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Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (83)

The effectiveness of the treatment will depend partly on the type and extent of scarring and the persons skin type

In the absence of BH 4 , the intermediate reacts with molecular oxygen, resulting in superoxide anion formation