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Figure 2 4 Strengthened concept of gutbone axis: an exploration of gutbone axis plus X 4.1 Extension on the boundary of gutbone axis Since the gut and bone are physically distant but closely interconnected, certain upstream, midstream, and downstream mediators, as well as other targets, are bound to exist to guarantee the integral harmonization of the organisms activities, theoretically

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doi: 10.1017/s0007114510000243 47 GradisteanuG