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This observation is not surprising as PDI knockdown would reduce the overall cellular pools of both reduced and oxidized forms of PDI, and the decreased availability of the oxidized PDI would decrease the signalling strength stemming from oxidized PDI-mediated NOS dimerization ( i.e

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Meanwhile, the unique metabolic characteristics of cancer cells, including their high metabolic demand, high ROS load, and the highly iron-dependent nature of tumor cells, particularly tumor stem cells, as well as their specific gene mutations, render certain types of cancer cells more susceptible to ferroptosis