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The use of dietary supplements by athletes is a serious concern because in many countries the manufacturing and labeling of supplements do not follow strict rules, which may lead to a supplement containing an undeclared substance that is prohibited under anti-doping regulations

These findings indicated that EA exhibited anti-inflammatory properties by stimulating sympathetic nerve resulting in the releasing of catecholamines from post-ganglionic nerve terminals, which link with -adrenoceptors on immune cells, consequently inhibiting their migration (Figure 2)

It regulates enzymes like sirtuins and PARPs, which are involved in cellular aging, inflammation, and stress response

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Some users develop chronic constipation requiring fiber supplementation, increased water intake, or occasional use of osmotic laxatives like polyethylene glycol