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Combined treatment of melatonin and erastin markedly reduced the tumor size in vivo, demonstrated no obvious systemic side effects, and significantly enhanced the apoptosis and ferroptosis levels in the tumor tissues, in parallel with decreased autophagy levels

Davidson MH

Mol Cell Biol 24:87538764

In following sections, we provide a comprehensive analysis of the fundamental knowledge on immunosuppressive TME modulating antitumor immune response, various resistance mechanisms to current immunotherapy, and advance strategies to prevent distinct challenges in the treatment of HGGs and BM

Xu X-M, Sansores-Garcia L, Chen X-M, Matijevic-Aleksic N, Du M, Wu KK (1999) Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate