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E2 enhances steroidogenesis, promotes the proliferation of ovarian granulosa cells, and supports follicular development by influencing the expression of genes that regulate the cell cycle

Carriers or diluents suitable for a selected dosage form and intended route of administration are well known in the art, and acceptable carriers or diluents for a chosen dosage form and method of administration can be determined using ordinary skill in the art

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Although astrocytes and SH-SY5Y cells are relevant, they do not represent the entire diversity of cell types in the nervous system, and SH-SY5Y cells, being an immortalized neuroblastoma-derived line, only partially recapitulate the molecular and functional properties of primary neurons

Some tech-savvy pet parents even use wearable devices to track their dog's heart rate patterns