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Dendritic cells and macrophages both have nAChR, which mediates inflammation

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55 Despite initial optimism about these products, both laboratory-based and epidemiologic studies indicate neither an individual, nor a public health benefit from low-tar cigarettes as compared to full-flavor varieties

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Association Between Initial Use of E-cigarettes and Subsequent Cigarette Smoking Among Adolescents and Young Adults: A systematic Review and Meta-analysis