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Siwek et al

Although the mechanism(s) underlying NASH progression remain to be fully elucidated, accumulating evidence suggests that both oxidative stress and the pro-inflammatory cytokine tumor necrosis factor- (TNF) are critical contributors in this process 5

Phosphorylated MLKL oligomerizes and translocates to the plasma membrane, where it forms pores that cause cell swelling, membrane rupture, and release of DAMP

10.3390/ijms25137169 282

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