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Prior to this report, there were no published reports of any pharmacologically and chemically attractive, selective small molecule activator probes to dissect the molecular mechanisms the apoptotic arm of the UPR activation, even at the phenotypic cell death level

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Interaction of SARS-CoV-2 proteins with specific host cellular targets could rewire sugar-, AA-, FA-, as well as nucleotide-metabolism(s), and distinctly alter or impair bioenergetics, immune response, and redox homeostasis in the human body, thereby facilitate viral life cycle 21,22