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This vicious cycle leads to the pathological fixation of metabolic reprogramming rather than a transient stress adaptation (Figure 1)

UMAP plots of adipocyte nuclei were visualized using Loupe Browser of the imported analysis from Seurat

1 2 3 Trends in Pharmacological Sciences

doi: 10.3168/jds.2021-20624 19 BrennerMAMarquesRSPosberghCJZezeskiALGearyTWMcCoskiSR

Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc