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It was also reported that these wounds had lower levels of pro-inflammatory markers such as tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9), all of which are involved in inflammation and tissue remodeling

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The endocannabinoid system and in particular the cannabinoid type-1 (CB 1 ) receptors are well known for their role in the reinforcing effects of addictive substances and long-term behavioral sensitization after chronic use