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Multiple behavior phenotypes of the fragile-X syndrome mouse model respond to chronic inhibition of phosphodiesterase-4D (PDE4D)

Reviewed by Natalie Punt, DVM This article was reviewed by Natalie Punt, DVM

This metabolic sensing function extends to regulation of key metabolic enzymes such as pyruvate dehydrogenase kinase, which is inhibited by low NAD+/NADH ratios, and lactate dehydrogenase, which is activated by high NADH levels, demonstrating the sophisticated regulatory networks that depend on NAD+ redox status

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