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Co-localization with RNA-polymerase II and binding to chromatin, as shown by co-precipitation with histone H3, further support a transcriptional regulation role for IGF-1R [88,89]

Hepatic mitochondria provide a hub for liver metabolic homeostasis by uniquely integrating or coordinating multiple metabolic pathways of carbohydrate, lipid, cholesterol, bile acid, and amino acids for energy homeostasis and by keeping the balance of reducing equivalents and intermediary metabolites in the liver and whole body via mitochondria-cytoplasm shuttles

S4), indicating its role in iron inter-tissue trafficking

Soeters PB, van de Poll MC, van Gemert WG, Dejong CH

Congenital lethal metaphyseal chondrodysplasia: a newly recognized complex autosomal recessive disorder