The dedicated cardiovascular trial did not find excess major events and reported lower all-cause mortality, but resting heart rate remains a titration marker rather than a one-time measurement. How to Titrate, and the Cost of Going Too Fast The final dose shapes the endpoint, but escalation speed is the largest modifiable driver of side effects
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Free copper can undergo redox cycling, leading to the formation of ROS, including hydroxyl radicals (HO) via Fenton and Harber-Weiss reactions [13, 17]
[5] Brcic, L., Kolenc, D., Blagaic, A.B., & Sikiric, P
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