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In:Deutsche Gesellschaft fr Neurologie Hauser RA, Hewitt LA, Isaacson S (2014) Droxidopa in patients with neurogenic orthostatic hypotension associated with Parkinsons disease (NOH306A)

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Rodent studies from the Kozlovskaya and Semenova groups at the Institute of Molecular Genetics report increased 5-hydroxyindoleacetic acid (5-HIAA) to serotonin ratios in the hypothalamus and striatum, suggesting accelerated serotonin turnover rather than raw 5-HT elevation