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As the clinical evidence section highlighted, there are now successful examples (e.g., the QLQX heart failure trial, and growing data on berberine)

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In addition, probiotics synthesize antimicrobial peptides, notably bacteriocins, which target pathogenic bacteria by disrupting cell membrane integrity, inhibiting cell wall synthesis, or interfering with essential metabolic pathways (29)

As indication bias is frequent in retrospective studies (the choice of treatment is generally influenced by patients characteristics), we used a propensity score to balance for these differences and recreate, as much as possible, the gold standard of a randomized trial

The sections were stained with hematoxylin and eosin (H&E) (Sakura finite), periodic acid-Schiff (PAS) (Scy Tek Laboratories, Logan, UT, USA) 23 , or MassonGoldner trichrome (MTC) (Sigma-Aldrich), and photographed using a BZ-9000 (Keyence, Osaka, Japan)