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PRE-surgical metformin in uterine malignancy (PREMIUM): a multi-center, randomized double-blind, placebo-controlled phase III trial

Le P, Tatar M, Dasarathy S, Alkhouri N, Herman WH, Taksler GB, et al

This method is often used for facial rejuvenation, hair restoration, and joint pain relief, among other applications

Because it had not been fully appreciated that relatively high doses of these antioxidants were needed to markedly alter lipid peroxidation rates in humans (390), one possibility is that the doses used in most large scale prevention trials were simply insufficient (390,391)