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Description

Ann Rheum Dis 81, 100107

The orally active PK activator mitapivat is the first approved therapeutic agent that is clinically beneficial for effective treatment of patients with PK deficiency (15, 16)

The observed depletion of carnosine likely reflects its rapid consumption due to redox imbalance in the inflamed lung, coupled with insufficient replenishment from remote synthesis sites (Figure 2H)