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[5] More Effective at Raising Arginine Levels - Studies show that L-citrulline supplementation increases plasma L-arginine concentrations more effectively than an equivalent dose of L-arginine itself

doi:10.1074/jbc.M007874200

Mechanism well-characterized in dermal fibroblasts

Preclinical evidence shows the significance of microbial metabolites and immune signaling in driving these effects, and recent clinical studies further supports these findings (Touchefeu et al., 2014