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Oxidative stress (free RONS) is generated by high concentrations of Ang II and low concentrations of Ang 17

It transfers hydride ions during redox reactions occurring in glycolysis, the TCA cycle, and oxidative phosphorylation

Despite their ability to provide temporary pain relief, it is increasingly clear that steroid injections are harmful to tendons in the long run, weakening them and making them more susceptible to injury

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The useful observation in this window is simple tolerability whether the chosen route is comfortable and consistent