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The APP_DAEF_10 proteoform, which increased in abundance with worsening pathology, consists of the first ten residues of the A42 peptide

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However, transcriptomic profiling of the hippocampus revealed that these behavioral improvements stemmed from entirely divergent biological programs

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Headline results announced in December 2024 and presented in full at the American Diabetes Associations 85th Scientific Sessions in June 2025, with simultaneous publication in the New England Journal of Medicine, showed that CagriSema produced a mean weight reduction of 22.7% at 68 weeks, significantly outperforming placebo