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[PubMed] [Google Scholar] 140.Zheng J.-L., Yu T.-S., Li X.-N., Fan Y.-Y., Ma W.-X., Du Y., Zhao R., Guan D.-W

[Google Scholar] 97.Lee Y.H., Seo Y.H., Kim J.H., Choi S.J., Ji J.D., Song G.G

However, in our hands Tm SAHH, as well as the other thermophilic enzymes, was enzymatically active without previous thermal activation

Similar to PROTAC 51 , PROTAC 52 exhibits robust cytotoxic activity against several FLT3-ITD mutant AML cells (IC 50 = 1.66 nM) by inducing a marked UPS-dependent degradation of the FLT3-ITD protein (DC 50 = 41.35 nM)